This club is located very centrally at the main shopping street Zeil. Some famous bands and DJs have been playing here and are playing, i.e. Boy George, Bush, Haim, Passenger, Mousse T. and so on. Locals like going there for After Work Parties, esp. on Thursdays
The Urban Club Band that is playing every Thursday is one of the best live bands in Frankfurt or even Germany. I'm actually absolutely not into live music but even I find them terrific! They cover modern songs in a very good way. But also the parties at the weekend are worth visiting.
go on their website to see if there is a concert or a party planned. If you come early you might get free entry.