Along the day, Florentine neighborhood is a busy area, filled with craftsmen, carpenters, upholsterers, cobblers and bakers (and tattoos studios - send me PM in case you need help with that). BUT, after sunset, it becomes a really bustling local bars area (especially on weekends).
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Firstly, Florentin is the most artistic and hipster area of TLV, filled with graffiti and tattoo artists. The main street is filled with small local bars, which gives you a great opportunity to meet another different touch of TLV. Plus, there are some really nice non-expansive places to eat.
I think the best time to visit is on Thursday nights.